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ENROLLING BY INVITATION
NCT07576036

International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia

Sponsor: Rochester General Hospital

View on ClinicalTrials.gov

Summary

Electronic medical records dating back as far as available for each center to identify patients admitted to the hospital with a serum sodium ≤110 mmol/l. Data on patient demographics, presenting symptoms, vital signs, laboratory findings, treatment given, sodium correction rates, presence of risk factors for osmotic demyelination syndrome (ODS) and outcomes including suspected and MRI-confirmed ODS, in-hospital death, and imaging confirmation of cerebral edema

Official title: Neurological Complications Associated With Serum Sodium ≤110 mmol/L and Its Treatment: An International Multi-Centre Retrospective Study.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

800

Start Date

2023-11-01

Completion Date

2026-06-30

Last Updated

2026-05-08

Healthy Volunteers

No

Interventions

DRUG

Hypertonic 3% saline

Rapid Correction of hyponatremia

Locations (1)

University of Pittsburgh School of Medicine

Pittsburgh, Pennsylvania, United States