Clinical Research Directory
Browse clinical research sites, groups, and studies.
Effect of Bismuth Add-on to Dual Therapy for Helicobacter Pylori Eradication
Sponsor: National Taiwan University Hospital
Summary
This study aims to compare the efficacy and safety of a bismuth-supplemented 14-day vonoprazan-based dual therapy ( triple therapy) versus a 14-day vonoprazan-based dual therapy without bismuth for first-line H. pylori eradication. Furthermore, the investigators will investigate the impact of these eradication regimens on the gut microbiota, the development of antibiotic resistance, and changes in metabolic syndrome indicators pre- and post-treatment.
Official title: Effect of Bismuth Add-on to Vonoprazan-Amoxicillin Dual Therapy for Helicobacter Pylori Eradication - A Multicenter Randomized Controlled Trial
Key Details
Gender
All
Age Range
20 Years - Any
Study Type
INTERVENTIONAL
Enrollment
990
Start Date
2026-04-08
Completion Date
2032-12-31
Last Updated
2026-05-08
Healthy Volunteers
No
Conditions
Interventions
Bismuth Add-on to Vonoprazan Dual Therapy
bismuth, vonoprazan and amoxicillin for 14 days
Vonoprazan dual therapy
vonoprazan and amoxicillin for 14 days
Locations (1)
National Taiwan University Hospital
Taipei, Taiwan