Clinical Research Directory

Inclusion Criteria: 1. Aged between 30 and 65 years old. 2. Office blood pressure with systolic blood pressure (SBP) 140-159 mmHg and/or diastolic blood pressure (DBP) 90-99 mmHg. 3. No intake of any antihypertensive drugs or have discontinued antihypertensive medication for at least 3 months prior to randomization; no intention to receive any other antihypertensive therapy within the 15-week study period. 4. Written informed consent has been obtained from the subject or their legally authorized representative after being informed of the potential risks. Exclusion Criteria: 1. Known or suspected secondary hypertension. 2. Contraindications to TI treatment or sham TI treatment, including intracranial metal implants (e.g., pacemaker, ventriculoperitoneal shunt, vascular clip), craniocerebral surgery within the last 6 months, history of intracranial tumor or hemorrhage; skin damage, infection, eczema or allergy at the stimulation site (frontal/temporal region); severe skin diseases (e.g., psoriasis). 3. Subjects with high risk of cerebrovascular disease indicated by cranial magnetic resonance imaging. 4. History of myocardial infarction or cerebral infarction. 5. Atrial fibrillation or other severe arrhythmias, such as severe bradycardia, third-degree atrioventricular block, or ventricular tachycardia. 6. Severe or unstable medical conditions, including severe hepatic dysfunction (defined as alanine transaminase or aspartate transaminase level more than 2 times the upper limit of normal), severe renal dysfunction (defined as serum creatinine level more than 1.5 times the upper limit of normal), and severe heart failure (New York Heart Association Class III and IV). 7. Females who are pregnant, breastfeeding, or planning to become pregnant within one year. 8. Individuals unable to cooperate due to mental illness or other reasons. 9. Participants enrolled in other clinical trials within 3 months prior to randomization. 10. Participants deemed ineligible for this trial for other reasons determined by the investigator.