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Calcium Replacement Therapy in Postoperative Hypoparathyroidism
Sponsor: Tartu University Hospital
Summary
The goal of this clinical trial is to evaluate whether a lower-dose calcium replacement therapy is non-inferior to a higher-dose regimen in preventing symptomatic hypoparathyroidism in patients following thyroidectomy. The hypothesis is: • lower-dose calcium replacement therapy is non-inferior to higher-dose therapy in preventing symptomatic hypoparathyroidism during the first two postoperative weeks Researchers will compare patients receiving a lower-dose calcium replacement regimen with those receiving a higher-dose regimen to assess whether the lower dose is not associated with a higher incidence of symptomatic hypoparathyroidism. Patients who develop post-thyroidectomy hypoparathyroidism are divided into groups for calcium replacement therapy. If they are asymptomatic, they will be scheduled for a follow-up visit at two weeks after surgery. During the follow-up visit, calcium metabolism will be evaluated, and treatment adjusted if necessary.
Official title: A Pilot Study of Calcium Replacement Therapy in Postoperative Hypoparathyroidism
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-11-18
Completion Date
2028-12
Last Updated
2026-05-11
Healthy Volunteers
No
Interventions
Calcium carbonate 1250 mg (500 mg elemental calcium) twice a day
One study group takes calcium carbonate 1250 mg (500 mg elemental calcium) twice a day (at lunchtime and in the evening)
Calcium carbonate 1250 mg (500 mg elemental calcium) 4 times a day
The second study group takes 1250 mg of calcium carbonate (500 mg of elemental calcium) four times a day (starting at noon, at approximately 4-hour intervals: at noon, in the early afternoon, in the evening, and before bedtime). This dosage regimen is prescribed because 500 mg of calcium can be absorbed at a time.
Locations (2)
East Tallinn Central Hospital
Tallinn, Other, Estonia
Tartu University Hospital
Tartu, Estonia