Clinical Research Directory

Inclusion Criteria: * I1: Male or female at least 18 years old. * I2: For Cohort A: patients with OSCC who undergo surgery. For cohorts B and C: patients with OPMD. * I3: Patient who has agreed to participate in this research and sign consent. * I4: Patient affiliated to a medical insurance. * I5: Patient who have not previously received any anticancer treatment (radiotherapy, chemotherapy, or immunotherapy) Exclusion Criteria: * NI1: For cohorts B and C: Patient at high risk of bleeding, such as those receiving anticoagulant or antiplatelet therapy, those with coagulation disorders, or those with a history of severe bleeding within the two weeks prior to enrollment. * NI2: Pregnant or nursing woman. * NI3: Contraindication to general anesthesia. * NI4: Suspicion of rare tumor of particular histology other than squamous cell carcinoma (Sarcoma...). * NI5: Patient under curatorial or guardianship or placed under the protection of justice.