Clinical Research Directory

Microplastics in Brain Hematomas and Neurological Outcomes After Intracerebral Hemorrhage

Sponsor: University of Campania Luigi Vanvitelli

Summary

This observational study investigates the presence of micro- and nanoplastics (MNPs) in surgically removed intracerebral hematomas and their association with neurological outcomes in patients with spontaneous intracerebral hemorrhage (ICH). Microplastics have recently been identified in human tissues and are increasingly recognized as potential contributors to inflammation and vascular dysfunction. However, their role in cerebrovascular diseases, particularly intracerebral hemorrhage, remains unknown. Patients undergoing surgical hematoma evacuation will be enrolled. Brain tissue and blood samples will be analyzed using advanced spectroscopic and imaging techniques to detect and characterize micro- and nanoplastics. The study aims to evaluate whether the presence of these particles is associated with increased inflammation, worse neurological outcomes, and higher risk of adverse cerebrovascular events. This research may provide novel insights into the impact of environmental pollutants on brain vascular disease and patient prognosis.

Official title: Plastic Accumulation in Residual Brain Tissues From Hemorrhagic Events: Neurological Outcomes and Pathogenetic Evidence (PARTENOPE Study)

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