Clinical Research Directory
Browse clinical research sites, groups, and studies.
Intravenous Dexamethasone (0 vs 4 vs 8 mg) as an Adjunct to PENG Block for Postoperative Analgesia in Total Hip Arthroplasty: A Randomized Double-Blind Trial
Sponsor: Poznan University of Medical Sciences
Summary
his study will test whether giving dexamethasone through a vein can improve pain control after total hip replacement surgery. Dexamethasone is commonly used to reduce nausea and may also help with pain, but it is not clear which dose works best. Patients will be randomly assigned to receive either no dexamethasone, 4 mg, or 8 mg, in addition to standard anesthesia and a nerve block (PENG block). The main goal is to see how long patients go without needing additional pain medication after surgery. The study will also look at pain levels, use of opioid painkillers, nausea and vomiting, blood sugar levels, and possible side effects.
Official title: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating Intravenous Dexamethasone (0 vs 4 vs 8 mg) as an Adjunct to PENG Block for Postoperative Analgesia in Total Hip Arthroplasty
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
198
Start Date
2026-05-08
Completion Date
2027-07-31
Last Updated
2026-07-01
Healthy Volunteers
No
Conditions
Interventions
Dexamethasone 4mg
Intravenous dexamethasone administered as a single dose after induction of anesthesia, at doses of 4 mg
Placebo
Intravenous administration of 0.9% sodium chloride in a volume identical to active treatment, given after induction of anesthesia.
Dexamethasone 8mg
Intravenous dexamethasone administered as a single dose after induction of anesthesia, at doses of 8 mg
Locations (1)
Poznan University of Medical Sciences
Poznan, Poland