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COMPLETED
NCT07581522
NA

Pharmacokinetics of Essential Oils in Different Capsules

Sponsor: University of Mississippi Medical Center

View on ClinicalTrials.gov

Summary

This open label study will recruit healthy adults to investigate the pharmacokinetics of oral ingestion of frankincense, lemon, and wild orange essential oils. This study will also evaluate whether the delivery matrix (capsule type) affects the pharmacokinetics of the oils. Secondary outcomes include safety markers (liver and kidney function, hematology, urinalysis, and adverse events).

Official title: Pharmacokinetic Evaluation of Essential Oils in Different Capsule Matrices

Key Details

Gender

All

Age Range

18 Years - 35 Years

Study Type

INTERVENTIONAL

Enrollment

19

Start Date

2025-07-02

Completion Date

2025-12-19

Last Updated

2026-05-12

Healthy Volunteers

Yes

Interventions

OTHER

Frankinscense Essential Oil Capsule

Frankincense essential oil capsule (150mg per visit). Participants will consume one capsule containing 150 mg of frankincense oil and 150 mg of olive oil at each visit. At the first visit, participants will receive the essential oil in a delayed-release hypromellose (HPMC capsule), followed by a HPMC Capsule at the second visit, and a Tapioca softgel capsule at the third visit.

OTHER

Lemon Essential Oil Capsule

Lemon essential oil capsule (150mg per visit). Participants will consume one capsule containing 150 mg of frankincense oil and one capsule containing 150 mg of olive oil at each visit. At the first visit, participants will receive the essential oil in a delayed-release hypromellose (HPMC capsule), followed by a HPMC Capsule at the second visit, and a Tapioca softgel capsule at the third visit.

OTHER

Wild Orange Essential Oil Capsule

Wild Orange essential oil capsule (150mg per visit). Participants will consume one capsule containing 150 mg of frankincense oil and once capsule containing 150 mg of olive oil at each visit. At the first visit, participants will receive the essential oil in a delayed-release hypromellose (HPMC capsule), followed by a HPMC Capsule at the second visit, and a Tapioca softgel capsule at the third visit.

Locations (1)

University of Mississippi Medical Center

Jackson, Mississippi, United States