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Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children
Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University
Summary
This study uses a prospective, up-and-down sequential allocation method to determine the median effective dose (ED50) and 95% effective dose (ED95) of alfentanil combined with propofol for successful laryngeal mask airway (LMA) insertion in children aged 7-12 undergoing elective day surgery.
Official title: Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children: A Prospective, Up-and-Down Sequential Allocation Study
Key Details
Gender
All
Age Range
7 Years - 12 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-05-01
Completion Date
2027-03-30
Last Updated
2026-05-12
Healthy Volunteers
No
Interventions
Alfentanil
All patients receive 2.5 mg/kg propofol injected over 30 seconds. Alfentanil is administered 1 minute prior to propofol. The dose is adjusted by steps of 2 µg/kg based on the previous patient's response (successful insertion = decrease dose; failed insertion = increase dose).
Locations (1)
Department of Anesthesiology, Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China