Clinical Research Directory

Inclusion Criteria: * Male and female participants, age between 18 to 65 years at the time of signing the informed consent. * Participants in good general health per medical evaluation (medical, allergy, and social history; physical and nasal examinations). * Participants who self-report acute nasal congestion as symptoms of an acute upper respiratory tract infection or allergies and a VAS score meeting the study-defined threshold. * Participants should abstain from use of nicotine products or any forms of nicotine replacement therapy, and consuming alcohol at least 12 hours prior to the study. Exclusion Criteria: * Any of the following conditions: severe or unstable or uncontrolled cardiovascular disease, cerebral or coronary insufficiency, Raynaud's Syndrome, thromboangitis obliterans, scleroderma, Sjögren's syndrome, renal or hepatic impairment, thyroid disease, diabetes, chronic congestion, COVID, influenza and enlarged prostate. * Participants with narrow angle glaucoma. * History of nasal surgery or nasal abnormalities. * Participants with history of frequent nosebleeds or with rhinitis medicamentosa. * Females who are pregnant, breast feeding, or planning a pregnancy. * Participants with inflammation of the skin and mucosa of nasal vestibule and encrustation (rhinitis sicca). * Presence of acute or chronic illnesses that may affect sensory function. * A history of drug or alcohol abuse within 12 months prior to the study visit. * A positive drug /alcohol/CO test. * History of sensitivity/ anaphylaxis to any of the study medications.