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RECRUITING
NCT07584278
NA

Probiotics and Biomarkers in Irritable Bowel Syndrome

Sponsor: Sahlgrenska University Hospital

View on ClinicalTrials.gov

Summary

The goal of this double-blind parallel-arm randomized controlled trial is to learn if a probiotic supplement (containing a new strain derived from L. reuteri DSM 17938) alters outcomes related to symptom severity and transit time in adults with irritable bowel syndrome (IBS). The main question it aims to answer is: Does the probiotic alter IBS symptom severity? Researchers will compare the probiotic to a placebo (a lookalike substance that contains no probiotic) to see if the probiotic works to alter outcomes. Participants will: Be randomized to either take the probiotic supplement or placebo supplement daily for 12 weeks. Visit the lab for 4 study visits (visit 1: screening and informed consent; visit 2: randomization, data collection, beginning the intervention; visit 3: end of intervention and data collection; visit 4: 3 month post intervention follow up and data collection). Provide biological samples (blood, stool, saliva, urine) Complete questionnaires

Official title: The Impact of Probiotics on Biomarkers and Symptom Severity in Irritable Bowel Syndrome

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

252

Start Date

2026-04-28

Completion Date

2031-05

Last Updated

2026-05-13

Healthy Volunteers

No

Interventions

OTHER

Probiotic Supplementation (Lactobacillus Reuteri)

Probiotic using a new strain derived from L. reuteri.

OTHER

Placebo Supplementation

A placebo supplement that is identical to the probiotic in formulation and packaging except that the probiotic bacteria is not present.

Locations (1)

Mag-tarmlab, Sahlgrenska University Hospital

Gothenburg, Sweden