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RECRUITING
NCT07584278
NA

Probiotics and Biomarkers in Irritable Bowel Syndrome

Sponsor: Sahlgrenska University Hospital

View on ClinicalTrials.gov

Summary

The goal of this double-blind parallel-arm randomized controlled trial is to learn if a probiotic supplement (containing a new strain derived from L. reuteri) alters outcomes related to symptom severity and transit time in adults with irritable bowel syndrome (IBS). The main question it aims to answer is: Does the probiotic alter IBS symptom severity? Researchers will compare the probiotic to a placebo (a lookalike substance that contains no probiotic) to see if the probiotic works to alter outcomes. Participants will: Be randomized to either take the probiotic supplement or placebo supplement daily for 12 weeks. Visit the lab for 4 study visits (visit 1: screening and informed consent; visit 2: randomization, data collection, beginning the intervention; visit 3: end of intervention and data collection; visit 4: 3 month post intervention follow up and data collection). Provide biological samples (blood, stool, saliva, urine) Complete questionnaires

Official title: The Impact of Probiotics on Biomarkers and Symptom Severity in Irritable Bowel Syndrome

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

252

Start Date

2026-04-28

Completion Date

2031-05

Last Updated

2026-06-01

Healthy Volunteers

No

Interventions

OTHER

Probiotic Supplementation (Lactobacillus Reuteri)

Probiotic using a new strain derived from L. reuteri.

OTHER

Placebo Supplementation

A placebo supplement that is identical to the probiotic in formulation and packaging except that the probiotic bacteria is not present.

Locations (1)

Mag-tarmlab, Sahlgrenska University Hospital

Gothenburg, Sweden