Clinical Research Directory

Inclusion Criteria: * Written informed consent provided by the participant * Age ≥ 18 years * Fully edentulous maxilla and mandible requiring rehabilitation with new complete removable dental prostheses * Patients with or without mandibular implants (implant overdenture or conventional denture) * Clinical indication for fabrication of new maxillary and mandibular complete removable dental prostheses * Currently wearing complete dentures, or a maxillary denture combined with a mandibular denture or overdenture * Ability and willingness to attend all scheduled follow-up visits for the duration of the study Exclusion Criteria: * Contraindications to the medical devices used, e.g. known hypersensitivity or allergy; * Known or suspected non-compliance, drug or alcohol abuse; Inability to follow the procedures of the investigation; * Enrolment of the investigator, his/her family members, employees and other dependent persons; * Reported severe bruxism or clenching habits, identified through patient interview and clinical examination, including self-reported grinding or clenching, partner reports, morning jaw discomfort, and other signs of parafunctional activity; * Width of the edentulous maxilla \>80 mm; * Width of the edentulous mandible \>80 mm; Vertical prosthetic space \<38 mm (maxilla or mandible); * Depression: Geriatric Depression Scale \>9; * Xerostomia: UFR ≤ 0.2ml/2min; * Dementia: Clock-Drawing Test ≤5; * Active peri-implant disease or instability of the two mandibular implants at baseline when implants are present; * Presence of an implant-retained prosthesis in the maxilla; * Planned implant-related surgical intervention during the study period.