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Vascular Endothelial Inflammation and Health Status In INOCA (VISION-INOCA)
Sponsor: NYU Langone Health
Summary
The purpose of this study is to evaluate coronary artery and peripheral vein vascular endothelial profiles in patients with ischemia with non-obstructive coronary arteries (INOCA) who undergo coronary function testing (CFT). The aims are: (1) Evaluate coronary artery endothelial profiles and associations with coronary microvascular dysfunction (CMD) in INOCA. (2) Assess brachial vein endothelial cell profiles in patients with INOCA and associations with CMD, and (3) Characterize relationships between endothelial signatures and anginal symptoms, functional status, and physical activity at baseline and 1-year follow-up.
Official title: A Single Center Diagnostic Study of Endothelial Inflammation and Health Status in Patients With Ischemia and Nonobstructive Coronary Arteries (INOCA)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
250
Start Date
2026-05
Completion Date
2031-03-01
Last Updated
2026-05-14
Healthy Volunteers
No
Interventions
Invasive coronary angiography
Participant will undergo invasive coronary angiography as clinically indicated (standard of care).
Coronary Artery Endothelial Cell Sampling
Endothelial cells will be obtained from clinical coronary guidewires after retrieval from the guide catheter.
Fitbit
Wearable activity monitoring device that measures physical activity based on the number of steps per day. The device also tracks sleep efficiency (exploratory) through a proprietary algorithm, and other health metrics. Daily step count and heart rate are recorded on the wearable device.
Invasive coronary function testing
Participants will undergo invasive coronary function testing as clinically indicated (standard of care).
Locations (1)
NYU Langone Health
New York, New York, United States