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Effectiveness of Surgery for Improving Survival in Oligometastatic Breast Cancer Patients
Sponsor: Sharif Medical Research Center
Summary
Breast cancer is the most common malignancy in women, with stage IV disease at diagnosis in 5-10% of cases. Oligometastatic breast cancer (OMBC), defined as limited metastases (≤3-5 in ≤1-2 organs), may have better outcomes. Systemic therapy is the cornerstone of treatment, while the role of surgery or radiotherapy for the primary tumour remains controversial. Current European Society for Medical Oncology(ESMO )and National Comprehensive Cancer Network(NCCN) guidelines advise systemic therapy as standard, reserving surgery mainly for palliation of local disease. Few Retrospective studies offering primary tumour surgery to oligometastatic breast cancer responding to systemic therapy suggest survival benefit, but several randomised trials to date showed inconsistent results. In Pakistan, data regarding survival pattern after breast surgery in oligometastatic breast cancer are scanty and this study would bridge this knowledge gap.
Official title: Effectiveness of Primary Tumor Surgery in Oligometastatic Breast Cancer for Improving Overall Survival: A Multicenter Quasi-Experimental Study
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2026-06-01
Completion Date
2031-06-01
Last Updated
2026-05-14
Healthy Volunteers
No
Conditions
Interventions
surgery in accordance with current clinical guidelines
MRM or BCS
modified radical mastectomy or breast conservation surgery
patients who receive systemic therapy and respond to treatment will undergo modified radical mastectomy or breast conservation surgery
Locations (1)
Department of Surgery and Surgical Oncology
Lahore, Punjab Province, Pakistan