Clinical Research Directory

Inclusion Criteria: * Randomized in the STEPCARE trial. * Out-of-hospital cardiac arrest. * Stable return of spontaneous circulation, defined in the parent STEPCARE protocol as at least 20 minutes without chest compressions. * Unconsciousness after sustained return of spontaneous circulation, defined as not being able to obey verbal commands, or intubated and sedated because of agitation. * Eligible for intensive care without restrictions or limitations. * Included in STEPCARE within the parent-trial inclusion window. * For STEP-PRESS analyses, availability of recorded STEPCARE blood-pressure data sufficient to calculate pulse pressure for the relevant analysis population. * For the primary STEP-PRESS analysis population: alive 12 hours after randomization, without mechanical circulatory support initiated before or within 24 hours after randomization, and with at least three valid recorded blood-pressure observations during 0 to 12 hours after randomization. Exclusion Criteria: * Withdrawal of consent for use of STEPCARE trial data. * Trauma or hemorrhage as the presumed cause of cardiac arrest. * Suspected or confirmed intracranial hemorrhage. * On extracorporeal membrane oxygenation before STEPCARE randomization. * Pregnancy. * Previously randomized in the STEPCARE trial. * For STEP-PRESS primary and 24-hour landmark analyses: mechanical circulatory support initiated before or within 24 hours after randomization. * For endpoint-specific analyses: missing data required to define the relevant exposure, outcome, or biomarker endpoint.