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Dual-Target CAR-NK Cells in Recurrent or Refractory Epithelial Ovarian Cancer
Sponsor: Beijing Biotech
Summary
This study evaluates the safety, tolerability, and preliminary anti-tumor activity of EB-DUALNK, a dual-target chimeric antigen receptor natural killer (CAR-NK) cell therapy, in adults with recurrent or refractory epithelial ovarian cancer. Candidates for targeting include GD2, MUC1, PSMA, and mesothelin. After baseline biomarker assessment (tumor antigen expression), the program will select the most suitable dual-target pair for clinical testing. Participants will receive lymphodepleting chemotherapy followed by EB-DUALNK infusion and safety/response follow-up.
Official title: A Phase 1/2, Open-Label, Dose-Escalation and Expansion Study of Dual-Target CAR-NK Cells (EB-DUALNK) Following Lymphodepleting Chemotherapy in Adults With Recurrent or Refractory Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma
Key Details
Gender
FEMALE
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2026-03-02
Completion Date
2028-03-17
Last Updated
2026-05-15
Healthy Volunteers
No
Interventions
EB-DUALNK
(dual-target CAR-NK cells; selected antigen pair from GD2, MUC1, PSMA, mesothelin)
Cyclophosphamide
lymphodepletion
Fludarabine
lymphodepletion
Locations (1)
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China