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RECRUITING
NCT07589543
PHASE1/PHASE2

Dual-Target CAR-NK Cells in Recurrent or Refractory Epithelial Ovarian Cancer

Sponsor: Beijing Biotech

View on ClinicalTrials.gov

Summary

This study evaluates the safety, tolerability, and preliminary anti-tumor activity of EB-DUALNK, a dual-target chimeric antigen receptor natural killer (CAR-NK) cell therapy, in adults with recurrent or refractory epithelial ovarian cancer. Candidates for targeting include GD2, MUC1, PSMA, and mesothelin. After baseline biomarker assessment (tumor antigen expression), the program will select the most suitable dual-target pair for clinical testing. Participants will receive lymphodepleting chemotherapy followed by EB-DUALNK infusion and safety/response follow-up.

Official title: A Phase 1/2, Open-Label, Dose-Escalation and Expansion Study of Dual-Target CAR-NK Cells (EB-DUALNK) Following Lymphodepleting Chemotherapy in Adults With Recurrent or Refractory Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma

Key Details

Gender

FEMALE

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

42

Start Date

2026-03-02

Completion Date

2028-03-17

Last Updated

2026-05-15

Healthy Volunteers

No

Interventions

BIOLOGICAL

EB-DUALNK

(dual-target CAR-NK cells; selected antigen pair from GD2, MUC1, PSMA, mesothelin)

DRUG

Cyclophosphamide

lymphodepletion

DRUG

Fludarabine

lymphodepletion

Locations (1)

Peking University Shenzhen Hospital

Shenzhen, Guangdong, China