Clinical Research Directory

Inclusion Criteria: 1. Both biological parents are of Han ethnicity; 2. Age range: 18 to 45 years old, gender not restricted; 3. Meets the clinical diagnostic criteria for bipolar disorder as stipulated in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); 4. Body Mass Index (BMI) ≥ 28 kg/m2, or for males, waist circumference ≥ 90 cm and for females, waist circumference ≥ 85 cm; 5. HAMD-24 score \< 7 points, YMRS score \< 5 points; 6. All included researchers and their family members have given informed consent for this study. Exclusion Criteria: 221/5000 1. Individuals with other DSM-5 spectrum disorders; 2. Mental disorders caused by substance abuse (such as alcohol, drugs, etc.), and those with severe physical illnesses; 3. Those who consumed food or microecological preparations containing probiotics, prebiotics, etc. within one week before enrollment, and had a history of respiratory, urinary, digestive system infections and antibiotic use within one month before enrollment; 4. Those currently having serious suicidal thoughts or behaviors, or those with severe agitation; 5. Those who cannot follow medical advice for treatment, or those without guardians; 6. Pregnant or lactating women, or those planning to become pregnant; 7. Those who cannot complete MRI examinations due to special conditions such as having metal implants or pacemakers in their bodies.