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A Trial Evaluating AMG 127 in Healthy Participants and Participants With Type 2 Diabetes Mellitus
Sponsor: Amgen
Summary
The main objective of this trial is to assess the safety and tolerability of AMG 127 as single dose and multiple doses in healthy participants and participants with type 2 diabetes mellitus (T2DM).
Official title: A Phase 1 Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 127 in Healthy Participants and Participants With Type 2 Diabetes Mellitus
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
162
Start Date
2026-06-11
Completion Date
2027-10-02
Last Updated
2026-06-23
Healthy Volunteers
Yes
Conditions
Interventions
AMG 127
AMG127 will be administered as either a SC injection or as an IV infusion.
Placebo
Placebo will be administered as either a SC injection or as an IV infusion.
Locations (1)
Translational Clinical Research LLC
Aventura, Florida, United States