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NOT YET RECRUITING
NCT07592169
PHASE2

Confirmatory Trial of Gamma Neurofeedback to Improve Working Memory in Schizophrenia

Sponsor: University of California, San Diego

View on ClinicalTrials.gov

Summary

This study is a confirmatory, double-blind, placebo-controlled randomized clinical trial (RCT) testing whether gamma EEG neurofeedback (EEG-NFB) improves working memory in adults with schizophrenia or schizoaffective disorder. Participants are randomly assigned to receive either active gamma EEG-NFB (real-time feedback of frontal gamma brain activity) or sham EEG-NFB (false pre-recorded feedback), twice weekly for 12 weeks. Working memory (N-back task), brain gamma coherence, and everyday community functioning are assessed at baseline, mid-treatment, end of treatment, and follow-up.

Official title: Confirmatory Efficacy Trial to Confirm the Effects of Gamma EEG-Neurofeedback on Working Memory in Schizophrenia

Key Details

Gender

All

Age Range

18 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

104

Start Date

2026-06-01

Completion Date

2030-05-31

Last Updated

2026-05-18

Healthy Volunteers

No

Interventions

BEHAVIORAL

EEG Neurofeedback

Gamma EEG neurofeedback delivered via CGX/Cognionics wireless headset (FDA cleared for research use). Active arm receives real-time gamma coherence feedback; sham arm receives pre-recorded feedback unrelated to own brain activity.