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Agreement Between Large Language Model-Generated Treatment Recommendations With Guideline-Based and Tumor Board Decisions in Gastrointestinal Cancer
Sponsor: Medizinische Hochschule Brandenburg Theodor Fontane
Summary
The goal of this observational study is to learn whether a computer program can suggest cancer treatments that match expert recommendations for people with gastrointestinal cancer (cancer of the pancreas, stomach, or colon and rectum). The main questions it aims to answer are: * Do the treatment suggestions from the computer program match current medical guidelines? * Do these suggestions match decisions made by a multidisciplinary tumor board (a team of cancer specialists)? Researchers will review existing medical records from people who have already been treated for these cancers. They will enter key clinical information into a computer program that uses artificial intelligence (AI). The program will generate treatment suggestions for each case. Researchers will then compare these suggestions with: * guideline-based treatment recommendations * decisions made by the tumor board This study will help researchers understand whether AI tools could support doctors in making cancer treatment decisions in the future.
Official title: Concordance of Large Language Model-Generated Treatment Recommendations With Multidisciplinary Tumor Board and Guideline-Based Decisions in Gastrointestinal Cancer: A Retrospective Cohort Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
30
Start Date
2025-01-01
Completion Date
2026-02-25
Last Updated
2026-05-18
Healthy Volunteers
No
Interventions
Treatment recommendation according to official German cancer guideline
Detailed treatment recommendation according to the official guideline of the Association of the Scientific Medical Societies in Germany (AWMF; Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften),
Treatment recommendation of a LLM
Structured clinical case summaries were analyzed by a GPT-4-class large language model to generate treatment recommendations.
Treatment recommendation of a multidisciplinary tumor board
Detailed treatment recommendation according to the case-specific postoperative tumor board review.
Locations (1)
University Hospital Brandenburg
Brandenburg an der Havel, Brandenburg, Germany