Clinical Research Directory

Key Inclusion Criteria: 1. Patients must meet the 2015 International Consensus Diagnostic Criteria for Neuromyelitis Optica Spectrum Disorder (NMOSD) and test positive for AQP4 antibodies. 2. Documented evidence of at least 1 relapse within 12 months before signing the informed consent form. 3. The Expanded Disability Status Scale (EDSS) score ≤ 8. 4. Female participants of childbearing potential must present a negative pregnancy test at screening and agree to use effective contraception throughout the study period. 5. Informed consent must be obtained from the patient or their legal representative, with a signed consent form must be provided. Key Exclusion Criteria: 1. Viral infections: Known HIV, active HBV, or active HCV. 2. Pregnant or breastfeeding women. 3. History of other autoimmune diseases requiring immunosuppressive therapy. 4. Use of any live vaccines against infectious disease within 6 weeks before enrollment. 5. History of bone marrow/hematopoietic stem cell or solid organ transplantation. 6. Patients deemed unsuitable for participation by the investigator.