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TACTIC-HF: Sequential Diuretic Strategies in Ambulatory Worsening Heart Failure
Sponsor: Lucrecia Maria Burgos
Summary
TACTIC-HF is a prospective randomized crossover trial designed to compare three ambulatory diuretic strategies in patients with worsening heart failure treated in a specialized heart failure day-hospital program. Participants will receive sequential treatment with: 1. intravenous furosemide alone, 2. intravenous furosemide combined with oral acetazolamide, and 3. intravenous furosemide combined with oral hydrochlorothiazide. The primary objective is to compare short-term natriuretic response between strategies. Secondary objectives include assessment of urine output, congestion parameters, and renal/electrolyte safety. Each participant will undergo repeated outpatient treatment sessions separated by washout periods, with standardized clinical and laboratory monitoring performed during each visit. The study aims to evaluate pragmatic and clinically applicable ambulatory decongestion strategies using approved therapies commonly available in real-world practice.
Official title: TACTIC-HF: Thiazide or Acetazolamide Combination Versus Intravenous Furosemide in Ambulatory Worsening Heart Failure - a Randomized Crossover Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-06-15
Completion Date
2027-01-15
Last Updated
2026-05-18
Healthy Volunteers
No
Conditions
Interventions
Intravenous furosemide bolus injections
Intravenous loop diuretic therapy administered during outpatient treatment sessions according to protocol-defined dosing categories.
ACETAZOLAMIDE oral capsule
Oral acetazolamide administered prior to intravenous loop diuretic therapy during outpatient treatment sessions
Hydrochlorothiazide (HCT)
Oral hydrochlorothiazide administered prior to intravenous loop diuretic therapy during outpatient treatment sessions.