Clinical Research Directory
Browse clinical research sites, groups, and studies.
NET-TIME: Inflammatory Tumor Microenvironment in Pituitary Neoplasm
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Summary
Over the past twenty years, a progressively increasing number of markers biochemical, clinical, imaging, histopathological or genetic have been suggested to attempt to predict aggression and therapeutic outcome, both in secretory PitNETs and in non-secretory PitNETs. In recent years, the microenvironment tumor (TEM) has been extensively studied in different malignancies, promoting the development of therapies target and immunotherapy with checkpoint inhibitors immune system (ICI). Data on TIME in PitNETs are scarce today and derive from studies conducted mainly on heterogeneous cases for type of PitNET. Therefore, the purpose of this research project is to investigate the TIME in PitNET, to identify immune biomarkers and new molecular pathways that can promote the use of ICI and target therapies in Aggressive PitNETs.
Official title: Inflammatory Tumor Microenvironment in Pituitary Neoplasm
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2023-06-03
Completion Date
2027-03-31
Last Updated
2026-05-18
Healthy Volunteers
Yes
Conditions
Locations (1)
Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC ENDOCRINOLOGIA
Rome, Lazio, Italy