Clinical Research Directory

Platelet-Rich Fibrin (PRF) vs Bone Graft With Membrane for Ridge Preservation After Tooth Extraction

Sponsor: Ohio State University

Summary

This study uses a natural material called Platelet-Rich Fibrin (PRF) to help improve healing after tooth removal. PRF is made from your own blood. A small amount of blood is taken from your arm and spun in a machine to make a thick, sticky layer full of platelets. These platelets help your body heal. PRF acts like a "natural bandage" and may help your gums and bone heal faster. Because it comes from your own body, it is safe and lowers the chance of infection or problems. The goal of this research is to see if adding PRF to a bone graft (used to fill the tooth socket after extraction) can help the area heal faster and grow more new bone. If you join this study, it will last about 4 months. You will have two teeth removed, and each socket will get a different treatment: 1. One socket (test side) will get PRF + bone graft (this combination is also called "sticky bone"). 2. The other socket (control side) will get a bone graft + a covering called a barrier membrane (made of collagen). We will compare how well the two sides heal by looking at: 1. How the gums close over the area 2. How much pain you feel 3. How much the bone changes 4. How much new bone grows You will come to the clinic for about 9 visits in total. These visits are part of your regular treatment, along with a few extra steps for the study. One possible risk is bruising or soreness from the blood draw. If we cannot collect enough blood (about 60-80 ml) because your veins are too small or hard to find, you will not continue in the study, and both sockets will be treated using the control method (bone graft + membrane).

Official title: Application of Platelet-Rich Fibrin Consolidated Bone Substitutes in Alveolar Ridge Preservation: A Randomized Controlled Study

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