Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity
Sponsor: Pfizer
Summary
The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes. About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe. People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.
Official title: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF ONCE-MONTHLY PF-08653944 IN ADULTS WITH OVERWEIGHT OR OBESITY (VESPER-6)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
954
Start Date
2026-06-10
Completion Date
2028-06-21
Last Updated
2026-08-17
Healthy Volunteers
No
Interventions
PF-08653944
By Subcutaneous Injection
Placebo
By Subcutaneous Injection
Locations (38)
San Fernando Valley Health Institute
Canoga Park, California, United States
Headlands Research California, LLC
Escondido, California, United States
ImmuniMet, LLC
Modesto, California, United States
ClearVue Eye Care
Roseville, California, United States
Clinical Trials Research
Sacramento, California, United States
University Clinical Investigators, Inc.
Tustin, California, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Southern California Retina Specialists
West Hills, California, United States
Nature Coast Clinical Research
Crystal River, Florida, United States
West Coast Eye Institute
Lecanto, Florida, United States
South Broward Research
Miramar, Florida, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States
West Coast Medical Associates
New Port Richey, Florida, United States
Center for Diabetes, Obesity and Metabolism Inc
Pembroke Pines, Florida, United States
Cedar Crosse Research Center
Chicago, Illinois, United States
MediSphere Medical Research Center, LLC
Evansville, Indiana, United States
Monroe Biomedical Research
Louisville, Kentucky, United States
Aa Mrc Llc
Flint, Michigan, United States
Albuquerque Clinical Trials, Inc.
Albuquerque, New Mexico, United States
Rochester Clinical Research, LLC
Rochester, New York, United States
Medication Management LLC
Greensboro, North Carolina, United States
Accellacare - Wilmington
Wilmington, North Carolina, United States
Jeffrey Coleman, OD
Wilmington, North Carolina, United States
Midwest Eye Center
Cincinnati, Ohio, United States
Velocity Clinical Research, Mt. Auburn
Cincinnati, Ohio, United States
VIP Trials
San Antonio, Texas, United States
York Clinical Research, LLC
Norfolk, Virginia, United States
CEPIC - Centro Paulista de Investigação Clínica
São Paulo, Brazil
Ocean West Research Clinic
Surrey, British Columbia, Canada
GA Research Associates Ltd.
Moncton, New Brunswick, Canada
Winterberry Research Inc.
Hamilton, Ontario, Canada
The Wharton Medical Clinic Clinical Trials Inc
Hamilton, Ontario, Canada
Canadian Phase Onward Inc.
Toronto, Ontario, Canada
Medical Corporation Heishinkai OCROM Clinic
Suita, Osaka, Japan
Tokyo Center Clinic
Chuo-ku, Tokyo, Japan
Tokyo-Eki Center-Building Clinic
Chuo-ku, Tokyo, Japan
Fukuwa Clinic
Chuo-ku, Tokyo, Japan
Medical Corporation Heishinkai ToCROM Clinic
Shinjuku-ku, Tokyo, Japan