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RECRUITING
NCT07595549
PHASE3

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

Sponsor: Pfizer

View on ClinicalTrials.gov

Summary

The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes. About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe. People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.

Official title: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF ONCE-MONTHLY PF-08653944 IN ADULTS WITH OVERWEIGHT OR OBESITY (VESPER-6)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

954

Start Date

2026-06-10

Completion Date

2028-06-21

Last Updated

2026-07-08

Healthy Volunteers

No

Interventions

DRUG

PF-08653944

By Subcutaneous Injection

OTHER

Placebo

By Subcutaneous Injection

Locations (19)

ImmuniMet, LLC

Modesto, California, United States

ClearVue Eye Care

Roseville, California, United States

Clinical Trials Research

Sacramento, California, United States

University Clinical Investigators, Inc.

Tustin, California, United States

Diablo Clinical Research, Inc.

Walnut Creek, California, United States

Nature Coast Clinical Research

Crystal River, Florida, United States

West Coast Eye Institute

Lecanto, Florida, United States

South Broward Research

Miramar, Florida, United States

Suncoast Clinical Research, Inc.

New Port Richey, Florida, United States

West Coast Medical Associates

New Port Richey, Florida, United States

MediSphere Medical Research Center, LLC

Evansville, Indiana, United States

Monroe Biomedical Research

Louisville, Kentucky, United States

Aa Mrc Llc

Flint, Michigan, United States

Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico, United States

Rochester Clinical Research, LLC

Rochester, New York, United States

Medication Management LLC

Greensboro, North Carolina, United States

Midwest Eye Center

Cincinnati, Ohio, United States

Velocity Clinical Research, Mt. Auburn

Cincinnati, Ohio, United States

VIP Trials

San Antonio, Texas, United States