Clinical Research Directory

Inclusion Criteria: 1. Aged 18 years or older 2. Hospitalized in the ICU for more than 48 hours 3. Informed consent obtained from the patient Exclusion Criteria: 1. Unstable patient 2. Known allergy to Gamma-Hydroxybutyrate or any of the excipients 3. Technical impossibility of performing polysomnography 4. Childbearing or Positive pregnancy test for women of childbearing age or breastfeeding 5. Patient who has already received the study treatment 6. History of chronic alcoholism 7. Uncontrolled epilepsy despite appropriate antiepileptic treatment 8. Traumatic brain injury or neurological lesion at risk of epilepsy in the last month 9. Severe hypertension: SBP \> 180 mmHg despite antihypertensive treatment 10. Hypokalemia \< 3.5 mmol/L despite potassium supplementation 11. Bradycardia due to intra-cardiac conduction disorders 12. Obstructive sleep apnea syndrome 13. Sodium restriction: Salt intake \< 3g/24h 14. Patients with known or suspected succinic semialdehyde dehydrogenase (SSADH) deficiency, given the risk of GHB accumulation due to impaired endogenous metabolism. 15. Patients receiving barbiturates at inclusion 16. Patients receiving opioids at inclusion for non-mechanically ventilated patient 17. Patients presenting with hypernatraemia (sodium \> 145 mmol/L) or hyperchloraemia (chloride \> 110 mmol/L) at inclusion 18. Patients with hepatic impairment (Child-Pugh B or C) 19. Deep sedation defined by a RASS score \< -2 20. Presence of mental confusion: Positive CAM-ICU 21. Moribund patient or high likelihood of death within 48 hours 22. Legal protection: guardianship, curatorship, or judicial protection 23. Lack of social security or on AME (state medical aid) 24. Participation in another interventional clinical trial related to the management of sleep disorders, delirium, or sedation in the ICU.