Clinical Research Directory

Inclusion Criteria: * Female patients aged 18 years or older. Clinical stage of breast cancer: T1-T4, N1-N3, M0. Axillary lymph node metastasis confirmed by fine-needle aspiration (FNA) or core-needle biopsy. Indicated for and planned to receive standard neoadjuvant chemotherapy (NAC) regimen. The biopsy-proven metastatic lymph node is clearly visible on ultrasound and suitable for clip placement. Completion of NAC followed by breast surgery and axillary lymph node dissection, with complete pathological results available. Underwent multimodal ultrasound monitoring during NAC, including conventional ultrasound, elastography, and contrast-enhanced ultrasound. Signed informed consent and willingness to complete all scheduled follow-ups. Exclusion Criteria: * Bilateral breast cancer. Patients who are not suitable for neoadjuvant chemotherapy or plan to receive endocrine or targeted therapy only. Prior breast or axillary surgery, chemotherapy, or other treatments that may affect the current therapeutic assessment. Presence of distant metastasis or extensive axillary invasion making clip placement or evaluation difficult. Pregnant or lactating women. Poor image quality on ultrasound or other imaging modalities. Inability to provide informed consent due to psychological, family, or social factors