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NCT07596524

Analysis of Different Second Line Treatment in Advanced NSCLC Patients Progressing After 1st Line Immune Checkpoint Inhibitor Therapy

Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

View on ClinicalTrials.gov

Summary

The second-line treatment options in clinical practice for immunotherapy progress are complex. Treatment strategies need to be selected based on different progression patterns. It is difficult to simultaneously explore multiple treatment modalities through previous clinical studies. Observational studies through real-world research can efficiently convert clinical practice data into clinical treatment evidence. This study aims to observe the treatment patterns and clinical outcomes of advanced NSCLC patients who received first-line immunotherapy checkpoint inhibitor treatment after progression, in order to provide guidance for the second-line treatment options for patients with first-line immunotherapy progress.

Official title: Analysis of Different Treatment Modalities and Clinical Outcomes in Advanced NSCLC Patients Progressing After First-Line Immune Checkpoint Inhibitor Therapy: An Observational Study Based on Real-World Data

Key Details

Gender

All

Age Range

1 Year - Any

Study Type

OBSERVATIONAL

Enrollment

300

Start Date

2026-07-01

Completion Date

2027-06-30

Last Updated

2026-05-19

Healthy Volunteers

No

Interventions

OTHER

Observation

The patients' second-line treatment received and the follow-up observations were retrospectively collected.

Locations (3)

Cancer Hospirtal, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

Cancer Hospirtal, Chinese Academy of Medical Sciences, Shenzhen

Shenzhen, Guangdong, China

Shanxi Provincial Cancer Hospital

Taiyuan, Shanxi, China