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NOT YET RECRUITING
NCT07596758
NA

Immediate Implant Placement With Subepithelial Connective Tissue Grafting and Probiotics

Sponsor: Kafrelsheikh University

View on ClinicalTrials.gov

Summary

The present study aims to evaluate and compare the clinical, radiographic, and biological peri-implant tissue outcomes of platelet-rich fibrin versus probiotics as adjuncts to immediate implant placement combined with subepithelial connective tissue grafting in adults requiring single immediate implant placement.

Official title: Comparative Evaluation of Platelet-Rich Fibrin Versus Probiotics as Adjuncts to Immediate Implant Placement Combined With Subepithelial Connective Tissue Grafting: Clinical, Biological, and Radiographic Peri-Implant Tissue Outcomes A Parallel-Arm Randomized Trial

Key Details

Gender

All

Age Range

20 Years - 45 Years

Study Type

INTERVENTIONAL

Enrollment

22

Start Date

2026-05-14

Completion Date

2027-05-30

Last Updated

2026-05-19

Healthy Volunteers

Yes

Interventions

PROCEDURE

Platelet-Rich Fibrin

platelet-rich fibrin will be prepared immediately before application using freshly drawn autologous venous blood and a standardized centrifugation protocol selected according to the equipment available in the study setting. The prepared PRF will be used as an adjunct to the immediate implant and subepithelial connective tissue grafting procedure according to the finalized protocol, either locally around the peri-implant site and/or in intimate relation to the grafted soft tissue to enhance healing and tissue maturation.

PROCEDURE

Probiotics

Probiotics probiotics will be administered as an adjunct to the immediate implant and subepithelial connective tissue grafting The mode of delivery, dose, and duration will be standardized for all patients allocated to this group.

Locations (1)

faculty of dentistry, kafrelsheikh University

Kafr ash Shaykh, Kafrelsheikh, Egypt