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Fecal Microbiota Transplantation in Parkinson's Disease.
Sponsor: Chang Gung Memorial Hospital
Summary
Fecal microbiota transplantation (FMT) is an effective and safe treatment for Clostridioides difficile infection (CDI). Though CDI is the only indication for FMT, more and more preliminary data on FMT in neurological disorders are reported due to gut-brain axis. This study is a pilot study to apply FMT on patients with Parkinson's disease (PD). The effect of FMT on motor and non-motor symptoms in PD will be also evaluated.
Official title: Fecal Microbiota Transplantation for the Treatment of Patients With Parkinson's Disease.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
58
Start Date
2026-09-01
Completion Date
2029-04-07
Last Updated
2026-05-19
Healthy Volunteers
No
Conditions
Interventions
Fecal microbiota transplantation
All subjects in the treatment group will receive FMT once. Recipients must adhere to a low-fiber diet for three days, and pre-treatment antibiotics with Vancomycin 125 mg, administered as 2 capsules every 6 hours for 3 days. After a 24-hour washout period, they underwent colon preparation followed by FMT. During the procedure, processed 250cc microbiota fluid from healthy donors, provided by the Chang Gung fecal bank, was administered into the terminal ileum or cecum via ileocolonoscopy. To ensure safety and traceability, only a single-donor microbiota is used. After FMT, patients were instructed to lie on their right side for at least 30 minutes.
Not received Fecal microbiota transplantation
All subjects in the Control group will not receive FMT.