Clinical Research Directory

Inclusion Criteria: * Individuals with poorly controlled diabetes and HbA1c levels between 7% and 9% * At least 15 natural teeth and, from a periodontal perspective: probing pocket depth (PPD) ≥ 6 mm, clinical attachment loss (CAL) ≥ 5 mm, radiographic bone loss extending to the middle or apical third of the root, and periodontitis-related tooth loss of ≤ 4 in different quadrants Exclusion Criteria: * Individuals who were pregnant or breastfeeding * Patients with a history of acute or chronic infection within the past 6 months * Patients who had undergone periodontal treatment within the past 6 months * Patients receiving systemic antibiotic therapy during the same period * Patients using non-steroidal anti-inflammatory drugs, phenytoin, calcium channel blockers or cyclosporine * Patients undergoing hormone therapy * Individuals who had used antibiotics or anti-inflammatory drugs regularly during the 3-month period following the start of the study * İndividuals with medical or psychological conditions that could affect the accurate understanding and completion of the questionnaires * Smokers