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Topical Capsaicin Versus Diclofenac for Chronic Temporomandibular Joint-Related Pain
Sponsor: Istanbul University
Summary
The goal of this clinical trial is to compare the effectiveness and safety of topical capsaicin cream and topical diclofenac gel in women with chronic temporomandibular joint-related pain. The main questions it aims to answer are: * Does topical capsaicin reduce pain intensity more effectively than topical diclofenac? * Do the treatments improve jaw function, pressure pain threshold, and neuropathic pain symptoms? Researchers will compare topical capsaicin cream with topical diclofenac gel to evaluate differences in pain relief and functional improvement. Participants will: * Apply the assigned topical medication four times daily for 7 days * Attend clinical examinations and pain assessments at baseline, Day 8, and Month 1 * Complete pain-related questionnaires and functional jaw measurements during follow-up visits
Official title: Topical Capsaicin Versus Diclofenac for Chronic Temporomandibular Joint-Related Pain: A Randomized, Prospective, Single-Blind Clinical Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-08-28
Completion Date
2026-04-06
Last Updated
2026-07-01
Healthy Volunteers
No
Interventions
Capsaicin Topical Cream
Topical capsaicin cream applied four times daily over the temporomandibular joint region for 7 days.
Diclofenac 1% Topical
Topical diclofenac diethylammonium gel applied four times daily over the temporomandibular joint region for 7 days.
Locations (1)
Istanbul University Faculty of Dentistry
Istanbul, Istanbul, Turkey (Türkiye)