Clinical Research Directory

Study period: Optum: Eligible cohort entry period from August 1, 2014 to August 31, 2024. Marketscan: Eligible cohort entry period from August 1, 2014 to September 31, 2023. Medicare: Eligible cohort entry period from August 1, 2014 to September 31, 2020. Inclusion Criteria: * At least 18 years of age * Heart failure with preserved ejection fraction * Structural heart disease * Previous HHF * BMI \< 45 kg/m2 * Type 2 diabetes mellitus * Use of oral diuretics Exclusion Criteria: * Concurrent use of both study drugs on cohort entry date * MI, CABG or other major cardiovascular surgery, GI surgery or disorder, stroke or TIA \[Day -91, Day 0\] * Implantable cardiac defibrillator \[Day -91, Day 0\] * Hypotension \[Day -91, Day 0\] * Major surgery \[Day -91, Day 0\] * GI surgery or disorder \[Day -91, Day 0\] * Cancer \[Day -730, Day 0\] * Heart transplant \[all available data, Day 0\] * Pacemaker \[all available data, Day 0\] * Liver disease \[all available data, Day 0\] * Atrial fibrillation \[Day -183, Day 0\] * Hypertension \[Day -183, Day 0\] * Impaired renal function \[Day -183, Day 0\] * Anemia \[Day -183, Day 0\] * History of ketoacidosis \[Day -183, Day 0\] * Pregnancy \[Day -183, Day 0\] * Cardiomyopathy \[Day -365, Day 0\] * Valvular heart disease \[Day -365, Day 0\] * Chronic pulmonary disease \[Day -365, Day 0\] * Combined comorbidity score \[Day -365, Day 0\] * Chronic alcohol and or drug abuse \[Day -365, Day 0\] * Noncompliance \[Day -365, Day 0\] * Acute decompensated HF \[Day -30, Day 0\] * Use of SGLT2i or DPP4i \[Day -183, Day 0\]