Clinical Research Directory

Inclusion Criteria: 1. Confirmed clinical diagnosis of ET 2. Isolated tremor syndrome, at least 3 years duration 3. Subjective complaint of tremor assessed and validated by physician 4. Must be willing to comply with the study protocol 5. English Proficiency 6. At least 18 years of age 7. At most 90 years of age Exclusion Criteria: 1. Severe microvascular disease or structural brain lesions equivalent to Fazekas scale of 3 or higher in the periventicular or deep white matter. 2. Subjects on blood thinning medications (e.g. Eliquis) 3. Recent stroke (within the last 6 months) 4. Implanted electrodes (e.g. DBS) in brain 5. History of aneurysm 6. History of cranial trauma resulting in fracture or traumatic brain injury 7. Subjects who are unable to cooperate with the testing. 8. Subjects who lack capacity to consent 9. Subjects with severe cardiac disease, increased intracranial pressure, or using a transcutaneous electrical nerve stimulation (TENS) unit. 10. Severe cardiac disease will be defined as any of the following: i) History of myocardial infarction within the past 6 months ii) Diagnosis of congestive heart failure with NYHA Class III or IV symptoms iii) History of unstable angina, life-threatening arrhythmias, or use of an implantable cardioverter-defibrillator (ICD) iv) Uncontrolled hypertension (SBP \>180 mmHg or DBP \>110 mmHg) despite medication v) Any condition judged by the study physician to place the subject at increased risk from study participation 11. Subjects with implanted medical devices 12. Subjects with a history of seizure disorder. 13. Subjects with contraindications to enter MRI environment 14. Subjects with a history of substance abuse. 15. Subjects who are currently pregnant. This will be verified by a urine test prior to beginning the study.