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Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery
Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
Summary
This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery. The primary goal is to determine if the choice of anesthetic technique influences the incidence or severity of this complication. Participants will be randomly assigned to one of the two anesthetic regimens during surgery. They will receive daily in-hospital assessments for lung injury and other outcomes and will be followed for clinical outcomes until 90 days after the procedure.
Official title: Inhalational Versus Intravenous Anesthesia on Lung Injury After Major Surgery in Patients With Sepsis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
480
Start Date
2026-08-15
Completion Date
2030-12-30
Last Updated
2026-05-22
Healthy Volunteers
No
Conditions
Interventions
Inhalation Anesthesia
The inhalation group will be maintained with inhaled sevoflurane and a continuous intravenous infusion of remifentanil.
intravenous anesthesia
The intravenous group will be maintained with continuous intravenous infusions of both ciprofol and remifentanil.
Locations (1)
The Sixth Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China