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Evaluation of Tissue and Circulating microRNA Profiles in Patients With Hepatocellular Carcinoma Subjected to Thermal Ablation
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Summary
The main objectives of this research project concern the identification of microRNAs circulating and of serum metabolites predictive of treatment response in patients with early stage hepatocellular carcinoma undergoing locoregional treatment with thermoablation. In addition, the molecular mechanisms involved in reprogramming will be identified metabolic via bioinformatics analysis and pretreatment liver biopsy analysis and analysis of screening on patient-derived primary lines for personalized therapy.
Key Details
Gender
All
Age Range
18 Years - 64 Years
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2026-03-26
Completion Date
2028-12-31
Last Updated
2026-05-22
Healthy Volunteers
Not specified
Conditions
Locations (1)
IRCCS Policlinico di Sant'Orsola
Bologna, Emilia-Romagna, Italy