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Blood Exosomal Multi-omics and Lung Radiomics for Predicting Efficacy and Prognosis of Severe Eosinophilic ACOS With Biologics
Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Summary
Firstly, to screen blood exosomal multi-omics (transcriptomics, proteomics, metabolomics) and lung radiomics (HRCT, Xe129MRI) biomarkers that can predict efficacy and prognosis in severe eosinophilic ACOS (asthma-COPD overlap) patients treated with different biologics (benralizumab, mepolizumab, dupilumab). Then, to prospectively follow patients for 48 weeks after biologic initiation and collect clinical data, blood samples, and imaging features. Finally, to build a multi-dimensional predictive model for efficacy and prognosis of severe eosinophilic ACOS.
Official title: Blood Exosomal Multi-omics and Lung Radiomics for Predicting Efficacy and Prognosis of Severe Eosinophilic ACOS (Asthma-COPD Overlap Syndrome) Treated With Different Biologics: A Real-World Observational Study
Key Details
Gender
All
Age Range
14 Years - Any
Study Type
OBSERVATIONAL
Enrollment
500
Start Date
2026-06-01
Completion Date
2028-07-01
Last Updated
2026-05-22
Healthy Volunteers
No
Locations (1)
Union hospital, Tongji Medical college, Huazhong University of Science and Technology
Wuhan, Hubei, China