Clinical Research Directory

Inclusion criteria : * Age ≥ 18 years * mRS ≤ 1 before stroke * Anterior circulation large vessel occlusion stroke eligible to mechanical thrombectomy (MT) within 24 hours of onset or unknown onset with a DWI-FLAIR mismatch * Large core defined either as: * ASPECTS 2-5 or a core volume between 70 and 130 ml on MRI or perfusion CT for patients with process times compatible with IVT administration within 4.5 hours of onset or unknown onset with process times compatible with IVT administration within 4.5 hours of last seen well or unknown onset with a DWI-FLAIR mismatch * ASPECTS 2- 5 with a core volume ≤ 70 ml and core/perfusion mismatch \> 1.2 for patients with process times compatible with IVT administration within 4.5 and 9 hours of onset, defined as the mid-point between last known to be normal and symptoms constatation in case of unknown onset * Written informed consent signed by the patient or the trustworthy person / family member / close relative, or inclusion in case of emergency (to note, written informed consent will be signed by the patient (if needed, by trustworthy person, family member or close relative) as soon as possible (article 35 of the European regulation N°536/2014)) Exclusion criteria : * Anterior circulation stroke with a distal occlusion not eligible to MT * Posterior circulation stroke * Pregnancy or breastfeeding woman * Any contraindication to IVT, based on the Metalyse SmPC and the latest AHA/ASA guidelines on IVT (Prabhakaran et al. Stroke. 2026), other than those related to the NIHSS score upper limit, infarct size and symptoms-to-onset time, such as (but not limited to): * Persistent incapacity to lower blood pressure under 185/110 mmHg * Respiratory or hemodynamic failure * Externalized bleeding * Hypersensitivity to the active substance or to any of its excipients * Hypersensitivity to gentamicin (a trace residue from the manufacturing process * Known haemorrhagic diathesis * Bacterial endocarditis, pericarditis * Acute pancreatitis * Significant impairment of hepatic function, including hepatic failure, cirrhosis, portal hypertension (oesophageal varices) and progressive hepatitis * Active ulcerative gastrointestinal disease * Neoplasia associated with an increased risk of haemorrhage * Known bleeding disorders, such as thrombocytopenia (platelet count \< 100 G/L) or severe coagulopathy (INR \> 1.7, activated partial thromboplastin time \> 40s or prothrombin time \> 15s) either currently or within the last 3 weeks * Treatment with effective doses of oral anticoagulants (e.g. vitamin K antagonists with an INR \> 1.7) * Any history of intracerebral neoplasm * History of intracranial / spinal surgery or acute spinal cord injury within 3 months * Recent ST-segment elevation myocardial infarction within 3 months * Major non-central nervous system surgery, biopsy of a parenchymal organ or significant trauma within the last 10 days * Recent moderate to severe traumatic brain injury * Known arterial or venous malformation, except unruptured intracranial aneurysm * History of intracerebral haemorrhage within 3 months * Known cerebral amyloid angiopathy * History of acute ischaemic stroke within 3 months * Any contra-indication to MT: * Contra-indication to femoral, radial or humeral arterial puncture * Allergy to iodinated contrast media * Known Renal insufficiency at inclusion time (confirmed biologically by a creatinine clearance \< 30 ml/min calculated with the Cockcroft-Gault formula) * Anticipated life expectancy of less than 3 months * Participation in another interventional clinical trial evaluating a health product or any randomized clinical trial * Absence of affiliation to National French social security system * Under legal protection measure (tutorship or curatorship) and patient deprived of freedom