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Performance of Clinical Metagenomics in Stool and Urine Samples for Unexplained Diseases Diagnostic and Emerging Diseases Surveillance in Immunocompromised Patients
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The study is based on the hypothesis that the concomitant use of mNGS in non-invasive samples (stool, urine) could improve the rate of detected pathogens in immunodeficient patients compared with mNGS performed in an invasive reference sample alone (blood, CSF, broncho-alveolar lavage fluid (BAL), tissue).
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
120
Start Date
2026-06-01
Completion Date
2028-09-01
Last Updated
2026-05-22
Healthy Volunteers
No
Interventions
Metagenomics
The intervention aims to increase pathogen detection of mNGS with the addition of non-invasive samples compared with invasive sampling alone
Locations (1)
Hôpital Necker - Enfants Malades
Paris, Île-de-France Region, France