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Effects of Different Forms of a Natural Heart Hormone on Blood Pressure and Fluid Balance in Healthy Volunteers
Sponsor: Peter Fruergaard Andersen
Summary
The human heart produces hormones that help regulate blood pressure and fluid balance in the body. One of these hormones is atrial natriuretic peptide (ANP). ANP lowers blood pressure by relaxing blood vessels and increasing urinary excretion by the kidneys. Previous research has demonstrated that ANP naturally carries a small sugar molecule attached. This sugar moiety is produced endogenously and can modify the biological activity of ANP. When this sugar is present, ANP may affect blood vessels and renal function differently compared with the non-glycosylated form. The present study examines how this sugar modification alters the physiological effects of ANP. This is achieved by administering ANP, either with or without the attached sugar molecule, via intravenous infusion. The study aims to determine whether glycosylated ANP differs from the native form in its effects on blood pressure and fluid balance.
Official title: Effects of Glycosylated Atrial Natriuretic Peptide on Blood Pressure and Fluid Balance in Healthy Volunteers
Key Details
Gender
MALE
Age Range
18 Years - 30 Years
Study Type
INTERVENTIONAL
Enrollment
17
Start Date
2022-05-01
Completion Date
2026-03-30
Last Updated
2026-05-26
Healthy Volunteers
Yes
Conditions
Interventions
Infusion of two different cardiac peptides plus vehicle
Interventions Original protocol: ANP: 200 pmol/kg/min for 120 minutes gANP: 200 pmol/kg/min for 120 minutes Amended protocol: ANP: 200 pmol/kg/min for 60 minutes gANP: 300 pmol/kg/min for 60 minutes Control: Saline infusion at 0.7 mL/kg/hour
Locations (1)
4) Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Copenhagen, Denmark