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Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques
Sponsor: Kazakh Eye Research Institute
Summary
This study compares ten modern vitreoretinal surgical techniques for full-thickness macular hole repair. Participants will be randomly assigned to one of the surgical approaches during pars plana vitrectomy, using stratified randomization based on macular hole size to ensure balanced groups. The main goal is to determine which technique provides the highest anatomical closure rate on optical coherence tomography (OCT) and the best visual outcomes. Follow-up visits are scheduled at Day 7, Month 1, and Year 1 after surgery to assess OCT findings, visual acuity, safety outcomes, and the need for reoperation.
Official title: Vitreoretinal Surgery for Full-Thickness Macular Hole: A Comparative Study of Ten Techniques
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-05-25
Completion Date
2028-05-27
Last Updated
2026-06-02
Healthy Volunteers
No
Conditions
Interventions
Pars Plana Vitrectomy (PPV)-Based Macular Hole Surgery
Pars plana vitrectomy (PPV) for full-thickness macular hole repair performed according to the randomized assigned technique (e.g., ERM peel, ILM peeling, ILM flap configurations, or macular edge hydrodissection), as specified in the protocol.
Autologous Platelet-Rich Plasma (PRP)
Autologous platelet-rich plasma (PRP) applied intraoperatively to the macular hole area as an adjunct to surgery, according to the study protocol.
Human Amniotic Membrane (hAM) Graft
Human amniotic membrane (hAM) graft placed intraoperatively for macular hole repair, according to the study protocol.
Locations (1)
Kazakh Eye Research Institute
Almaty, Almaty, Kazakhstan