Clinical Research Directory

Inclusion Criteria: * Diagnosis of rosacea according to the criteria established by the ROSacea COnsensus (ROSCO) 2019 guidelines. * Presence of obvious facial erythema accompanied by significant burning and tingling sensations, with subjective symptoms (e.g., burning and tingling) being more severe than the observable clinical signs. * Refractory facial erythema despite conventional treatment, including antibiotics (metronidazole, doxycycline, and minocycline), oral isotretinoin, and oral beta-blockers. Exclusion Criteria: * Facial inflammatory dermatoses such as acne, contact dermatitis, seborrheic dermatitis, or other facial skin diseases. * Pregnancy or lactation. * Hepatic or renal insufficiency. * Ongoing treatment with long-term topical glucocorticoids or retinoids.