Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years, able to understand and sign the informed consent form. * Confirmed HIV infection. * Baseline CD4+ T-lymphocyte count \< 100 cells/μL. * Confirmed active pulmonary tuberculosis. * Agree to receive antituberculosis treatment and antiretroviral therapy during the study period. Exclusion Criteria: * Known or suspected resistance to any of the drugs in the regimen, including rifapentine, moxifloxacin, rifampicin, isoniazid, ethambutol, and pyrazinamide. * Body weight \< 40 kg. * Received the current tuberculosis treatment for more than 7 days. * Complicated with tuberculous meningitis or other severe forms of tuberculosis. * Severe liver dysfunction (ALT or AST \> 5 times the upper limit of normal, ULN). - - Severe renal dysfunction (eGFR \< 30 mL/min/1.73m²). * Baseline electrocardiogram (ECG) showing QTc interval \> 500 ms. * Pregnant or lactating women. * Presence of other conditions deemed inappropriate for study participation by the investigators.