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Azithromycin for Cerclage Prophylaxis
Sponsor: Wake Forest University Health Sciences
Summary
The primary goal is to assess the effectiveness in pregnancy prolongation utilizing azithromycin at the time of transvaginal cervical cerclage placement.
Official title: Evaluating Azithromycin Prophylaxis and Mycoplasma Prevalence in High-Risk Pregnancies Requiring Cerclage: A Prospective Cohort Study
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-09
Completion Date
2028-12
Last Updated
2026-08-27
Healthy Volunteers
No
Conditions
Interventions
Azithromycin Prophylaxis
500 mg of IV azithromycin prior to cerclage placement in the operating room or pre-operative area.
Azithromycin Placebo
normal saline placebo IV infusion prior to cerclage placement in the operating room or pre-operative area
Cefazolin
All participants will receive standard of care cefazolin. First dose is to be given preoperatively, and the next two doses to be given 8 and 16 hours postoperatively. Participants weighing less than 100 kg will receive 2 g cefazolin, and those weighing 100 kg or more will receive 3 g cefazolin.
Progesterone
progesterone 200 mg nightly after cerclage placement until 36 weeks gestation
Locations (2)
Advocate Christ Medical Center
Oak Lawn, Illinois, United States
Advocate Lutheran General Hospital
Park Ridge, Illinois, United States