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Estimation of the Prevalence of Microcirculatory Dysfunction in Uremic Cardiopathy Among Dialysis Patients
Sponsor: Centre Hospitalier Departemental Vendee
Summary
Patients with end-stage renal disease have a high burden of cardiovascular mortality, yet ischemic heart disease is often asymptomatic and difficult to diagnose in this population. Recent data suggest that microvascular coronary dysfunction may contribute significantly to myocardial ischemia in dialysis patients, but its true prevalence remains unknown. This study aims to evaluate microcirculatory coronary impairment in hemodialysis patients using invasive coronary angiography with measurement of coronary flow reserve (CFR), index of microcirculatory resistance (IMR). The study will also describe the clinical and biological characteristics associated with microvascular dysfunction in this population, in order to better understand the mechanisms of uremic cardiomyopathy and improve cardiovascular risk stratification.
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2027-09
Completion Date
2028-09
Last Updated
2026-05-27
Healthy Volunteers
No
Conditions
Interventions
Transthoracic ultrasound at rest
Transthoracic ultrasound at rest
Cardiological stress test
Left to the discretion of the centre: dobutamine echocardiography or myocardial scintigraphy.
Coronary angiography
Even even if the stress test comes back normal (these tests appear to be less effective at diagnosing microcirculatory abnormalities)
Locations (1)
Centre Hospitalier Départemental Vendée
La Roche-sur-Yon, France