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NOT YET RECRUITING
NCT07608679
NA

Estimation of the Prevalence of Microcirculatory Dysfunction in Uremic Cardiopathy Among Dialysis Patients

Sponsor: Centre Hospitalier Departemental Vendee

View on ClinicalTrials.gov

Summary

Patients with end-stage renal disease have a high burden of cardiovascular mortality, yet ischemic heart disease is often asymptomatic and difficult to diagnose in this population. Recent data suggest that microvascular coronary dysfunction may contribute significantly to myocardial ischemia in dialysis patients, but its true prevalence remains unknown. This study aims to evaluate microcirculatory coronary impairment in hemodialysis patients using invasive coronary angiography with measurement of coronary flow reserve (CFR), index of microcirculatory resistance (IMR). The study will also describe the clinical and biological characteristics associated with microvascular dysfunction in this population, in order to better understand the mechanisms of uremic cardiomyopathy and improve cardiovascular risk stratification.

Key Details

Gender

All

Age Range

18 Years - 90 Years

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2027-09

Completion Date

2028-09

Last Updated

2026-05-27

Healthy Volunteers

No

Conditions

Interventions

DIAGNOSTIC_TEST

Transthoracic ultrasound at rest

Transthoracic ultrasound at rest

DIAGNOSTIC_TEST

Cardiological stress test

Left to the discretion of the centre: dobutamine echocardiography or myocardial scintigraphy.

DIAGNOSTIC_TEST

Coronary angiography

Even even if the stress test comes back normal (these tests appear to be less effective at diagnosing microcirculatory abnormalities)

Locations (1)

Centre Hospitalier Départemental Vendée

La Roche-sur-Yon, France