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Cognitive Behavioral Therapy Added to Risperidone for Schizophrenia
Sponsor: Hasanuddin University
Summary
This study evaluated whether cognitive behavioral therapy (CBT), when added to risperidone treatment, improves cognitive function and serum brain-derived neurotrophic factor (BDNF) levels in patients with schizophrenia. Participants were adults with stable-phase schizophrenia who were receiving risperidone therapy. They were assigned to either a control group receiving risperidone alone or an intervention group receiving risperidone plus 10 weekly CBT sessions. Cognitive function was assessed using the Indonesian version of the Cognitive Assessment Interview (CAI-Ina). Serum BDNF levels were measured from blood samples using an enzyme-linked immunosorbent assay (ELISA). Measurements were performed at baseline and after 10 weeks. The study was conducted at Rumah Sakit Khusus Daerah Dadi, South Sulawesi, Indonesia.
Official title: Effectiveness of Cognitive Behavioral Therapy as Adjunctive Therapy on Cognitive Function and Serum Brain-Derived Neurotrophic Factor Levels in Patients With Schizophrenia Receiving Risperidone Therapy
Key Details
Gender
All
Age Range
20 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2025-11-01
Completion Date
2026-01-31
Last Updated
2026-05-27
Healthy Volunteers
No
Conditions
Interventions
Risperidone 4 to 6 mg/day
Risperidone was administered as antipsychotic therapy for patients with schizophrenia. Participants in both study groups received risperidone therapy according to the study protocol.
Cognitive Behavioral Therapy
Cognitive behavioral therapy was delivered as an adjunctive intervention to risperidone therapy. The intervention consisted of 10 weekly sessions over 10 weeks, with each session lasting approximately 30 minutes. Sessions included engagement, cognitive formulation, appraisal exploration, belief evaluation, gentle reality testing, alternative explanations, behavioral experiments, coping strategy enhancement, insight building, relapse prevention, and future planning.
Locations (1)
Rumah Sakit Khusus Daerah (RSKD) Dadi Provinsi Sulawesi Selatan
Makassar, South Sulawesi, Indonesia