Clinical Research Directory

Inclusion Criteria: 1. Male or female subject ≥ 20 to ≤ 65 years of age at the time signing informed consent form. 2. Body weight ≥50 kgs 3. Must be scheduling to receive a BNT162b2 mRNA COVID-19 vaccine 4. Being able to comply with the study protocol 5. Being able to independently provide written informed consent Exclusion Criteria: 1. Taking antibiotic at enrollment 2. Taking immunomodulatory (e.g., steroid) or anti-histamine drugs 3. Took pre- or probiotics within the past 30 days 4. Being to expected to take other probiotic supplement during the study period 5. Being expected to take antibiotic during the study period 6. A history of hypersensitivity or severe allergic reaction to any components of the probiotics or placebo supplement 7. Pregnant or breastfeeding 8. Having a severe immunocompromised disorder (e.g. HIV infection) 9. Solid organ or bone marrow transplant recipients 10. Major gastrointestinal surgery within 3 months before enrollment 11. Having severe active gastrointestinal conditions, including inflammatory bowel disease or diverticulitis 12. No self-reported symptoms of an upper airway infection with the past 2 weeks 13. A history of SARS-CoV-2 infection 14. Previously participated in investigational study involving SARS-CoV-2 vaccines or therapies