Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery

NOT YET RECRUITING

NCT07612709

NA

Sponsor: Medical University of Vienna

Summary

This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in patients at high-risk for developing severe pulmonary complications after cardiac surgery.

Official title: Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery in Patients at Increased Risk for Severe Postoperative Pulmonary Complications

Key Details

Gender

All

Age Range

65 Years - Any

Study Type

INTERVENTIONAL

Enrollment

45

Start Date

2026-10-01

Completion Date

2029-07-31

Last Updated

2026-05-29

Healthy Volunteers

No

Conditions

Lung Protective Ventilation Cardiopulmonary Bypass High-risk Cardiac Patients Lung Ultrasound Lung Water Assessment Pulmonary Complications in Surgical Patients Single-lung Ventilation Chest X-ray for Clinical Evaluation Electrical Impedance Tomography (EIT)Lung Compliance Oxygenation Indices Biomarkers of Vascular Endothelial Injury

Interventions

PROCEDURE

Ventilated lung

This lung will be ventilated during cardiopulmonary bypass using volume-controlled ventilation with a tidal volume of 3 mL/kg ideal body weight, a PEEP of 5 cmH2O, a respiratory rate of 10/min, and a fraction of inspired oxygen of 30%.

PROCEDURE

Non-ventilated lung.

The contralateral lung will not be ventilated during cardiopulmonary bypass and will be allowed to collapse.

Locations (1)

General Hospital Vienna

Vienna, State of Vienna, Austria

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