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A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk
Sponsor: Eli Lilly and Company
Summary
Lipoprotein(a), also known as Lp(a), is a protein that carries cholesterol and proteins in your blood. People with high Lp(a) have a higher risk for heart disease. The main purpose of the study is to investigate how lepodisiran, compared to a placebo, affects the amount and type of plaque in the heart's vessels using an imaging technology known as Coronary Computed Tomography Angiography (CCTA) in adults who have high levels of Lp(a). Participation will last about 120 weeks.
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial of Lepodisiran to Investigate the Effect on Coronary Plaque in Adults With Elevated Lp(a) Who Have Established Atherosclerotic Cardiovascular Disease or Are at Risk for a First Cardiovascular Event
Key Details
Gender
All
Age Range
45 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
252
Start Date
2026-05
Completion Date
2029-04
Last Updated
2026-05-29
Healthy Volunteers
No
Interventions
Lepodisiran
Administered SC
Placebo
Administered SC
Locations (58)
UCSD - Altman Clinical and Translational Research Institute (ACTRI)
La Jolla, California, United States
Valley Clinical Trials, Inc.
Northridge, California, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, United States
Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine Care
Fort Lauderdale, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Merritt Island Medical Research, LLC
Merritt Island, Florida, United States
Inpatient Research Clinic
Miami Lakes, Florida, United States
Clinical Site Partners, LLC dba Flourish Research
Winter Park, Florida, United States
CARE Institute - High Desert
Meridian, Idaho, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Profound Research LLC
Farmington Hills, Michigan, United States
Vector Clinical Trials
Las Vegas, Nevada, United States
Heart and Vascular Research at WellSpan Health
York, Pennsylvania, United States
Intermountain Medical Center
Murray, Utah, United States
Virginia Heart - Leesburg
Leesburg, Virginia, United States
Carilion Clinic
Roanoke, Virginia, United States
Eastside Research Associates
Redmond, Washington, United States
Nightingale Research
Adelaide, Australia
University of the Sunshine Coast (UniSC) Clinical Trials - Birtinya
Birtinya, Australia
Core Research Group
Brisbane, Australia
Advara HeartCare - Burwood
Burwood, Australia
Advara HeartCare Joondalup
Joondalup, Australia
Advara HeartCare Leabrook
Leabrook, Australia
AIM Research
Merewether, Australia
Advara HeartCare - Mulgrave
Mulgrave, Australia
USC Clinical Trials Brisbane (South Bank)
South Brisbane, Australia
Clinitrials
West Perth, Australia
Fakultni Nemocnice u sv. Anny v Brne
Brno, Czechia
EFERTUS healthcare s.r.o.
Brno, Czechia
Top Moravia Health
Brno, Czechia
Fakultni Nemocnice u sv. Anny v Brne
Brno, Czechia
Óbudai Egészségügyi Centrum
Budapest, Hungary
Semmelweis University
Budapest, Hungary
Szabolcs Szatmár Bereg Vármegyei Oktatókórház
Nyíregyháza, Hungary
Medisch Spectrum Twente
Enschede, Netherlands
Ziekenhuis St. Jansdal
Harderwijk, Netherlands
Alrijne Ziekenhuis, locatie Leiderdorp
Leiderdorp, Netherlands
VieCuri Medisch Centrum, locatie Venlo
Venlo, Netherlands
CHUAC-Complejo Hospitalario Universitario A Coruña
A Coruña, Spain
Parc de Salut Mar - Hospital del Mar
Barcelona, Spain
Hospital Quiron Barcelona
Barcelona, Spain
Hospital Universitario Reina Sofia
Córdoba, Spain
Hospital Insular de Gran Canaria
Las Palmas de Gran Canaria, Spain
Hospital Universitario Ramón y Cajal
Madrid, Spain
Hospital Clinico San Carlos
Madrid, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Hospital Universitario Virgen Del Rocio
Seville, Spain
Hospital General Universitario de Valencia
Valencia, Spain
FutureMeds - Birmingham
Birmingham, United Kingdom
Bristol Royal Infirmary
Bristol, United Kingdom
Cheadle Community Hospital
Cheadle, United Kingdom
Royal Lancaster Infirmary
Lancaster, United Kingdom
Lincoln County Hospital
Lincoln, United Kingdom
Futuremeds-Newcastle
Newcastle, United Kingdom
The John Radcliffe Hospital
Oxford, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, United Kingdom
Lister Hospital
Stevenage, United Kingdom
FutureMeds Teesside - Middlefield Centre
Stockton-on-Tees, United Kingdom