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Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children
Sponsor: University of Wisconsin, Madison
Summary
This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit (PICU). TCD is already used for clinical reasons in many children, but it is not part of routine monitoring for every critically ill child. By using TCD, the investigators hope to better understand how brain blood flow changes during illness. They will also track children's functional status from before their illness to the time of PICU discharge to explore how brain blood flow patterns relate to neurological outcomes.125 participants will be enrolled and will be on study while in the PICU, estimated to be 3-14 days.
Official title: Transcranial Doppler Assessment of Cerebral Autoregulation and Blood Flow Velocity Patterns in Critically Ill Children: A Prospective Observational Study
Key Details
Gender
All
Age Range
1 Day - 17 Years
Study Type
OBSERVATIONAL
Enrollment
125
Start Date
2026-07
Completion Date
2028-05
Last Updated
2026-07-06
Healthy Volunteers
No
Conditions
Interventions
Transcranial Doppler
TCD measurements synchronized to arterial blood pressure and ventilatory data, performed once daily for up to 5 days during PICU admission plus one additional pre-extubation scan if applicable, approximately 30 minutes each. Bilateral middle cerebral artery (MCA) insonation performed at each session.
Locations (1)
American Family Children's Hospital PICU
Madison, Wisconsin, United States